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Cetylpyridinium chloride ua kev kho rau COVID-19

Cov kev sim tau qhia txog qhov siab ntawm quaternary ammonium cov tshuaj tua kab mob ua kev kho rau ntau yam kab mob, nrog rau cov mob coronaviruses: cov yeeb yam no los ntawm kev txiav tawm cov kev tiv thaiv lipid txheej uas tau thaiv cov kab mob zoo li SARS-CoV-2 cia siab rau. Quaternary ammonium tebchaw tau pom zoo los tua cov kab mob thiab muaj ntau dua li 350 yam khoom ntawm EPA Cov Ntawv N: Cov tshuaj tua kab mob rau kev siv tiv thaiv SARS-CoV-2 (Cov Khoom Siv Ntxiv. Cov tshuaj tua kab mob ua kom sib xyaw thiab lub sijhawm sib chwv (cuam tshuam nrog ntau cov kab mob) rau ntau ntawm cov tshuaj tua kab mob Cov tshuaj lom rau ntawm EPA cov npe tau tshaj tawm thiab> 140 tuaj yeem ua rau tus kab mob tsis ua haujlwm sai hauv ob peb feeb (18).
Cov ntaub ntawv no coj peb kev tshawb nrhiav ntau dua rau cov quaternary ammonium tebchaw nrog kev ua si tiv thaiv tus kabmob coronaviruses thiab tej zaum kev txheeb xyuas cov tshuaj muaj kuab tshuaj uas twb tau sim hauv qhov chaw kuaj mob thiab tuaj yeem siv los ua cov kev kho mob rau COVID-19. Ib qho ntawm cov tshuaj tua kab mob uas tau pom tias muaj kev puas tsuaj rau cov kabmob (Cov Khoom Pab Ntxiv) thiab siv dav hauv cov khoom siv tu tus kheej yog cetylpyridinium chloride. Cov tshuaj sib tov no pom muaj ntau hauv cov tshuaj yaug qhov ncauj thiab muaj npe los ntawm FDA raws li kev saib xyuas kev nyab xeeb (GRAS) xws li tias nws tseem raug siv ua cov tshuaj tua kabmob rau cov nqaij thiab nqaij qaib (txog li 1%). Cetylpyridinium chloride tau siv rau hauv ntau qhov kev sim tshuaj, suav nrog rau kev kho mob los ntawm kev ua pa ua pa rau kev siv nws txoj kev siv tshuaj tiv thaiv kab mob. Cetylpyridinium yuav txhawb nqa tus kab mob inactivation los ntawm kev rhuav tshem lub kaus ncauj dhau los ntawm nws cov lysosomotropic kev ua, uas, raws li tau tham saum toj no, yog muaj rau quaternary ammonium compounds. Qhov no ua rau muaj lus nug txog qee cov tshuaj pom tseeb nrog kev ua haujlwm tiv thaiv kabmob tiv thaiv SARS-CoV-2 hauv vitro coj zoo ib yam, uas lawv yuav rhuav tshem tus kab mob capid raws li nthuav tawm hauv lysosome lossis endosomes thiab thaum kawg thaiv cov kab mob nkag. Cov kev tshawb fawb luam tawm ntxiv tau hais tias cov nyhuv no tuaj yeem tsim los ntawm kev siv Cathepsin-L inhibitors. 

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Cetylpyridinium chloride (CPC)

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Quaternary ammonium tebchaw nrog paub cov kab mob coronavirus

Molecule

Antiviral yam kev ua

Lub Tshuab

FDA pom zoo

Kev Siv

Ammonium Chloride Murine coronavirus, mob siab C, Lysosomotropic Yog lawm Kev siv ntau yam nrog rau cov teeb meem metabolic acidosis.
Cetylpyridinium chloride Khaub thuas, kab mob siab B, poliovirus 1 Lub hom phiaj capsid thiab yog lysosomotropic Yog, GRAS Antiseptic, tshuaj yaug qhov ncauj, hnoos lozenges, khoom tu tus kheej, tshuaj ntxuav tu thiab lwm yam.

Sijhawm Tshaj Tawm: Plaub Hlis-16-2021